WOUND
Wound complications such as infection reduce the patient’s quality of life.
Conventional antiseptics and antibiotics used to prevent or treat infections have long been controversial due to cytotoxicity and proliferation of antibiotic-resistant bacteria.
While hypochlorous acid (HOCl) has a competitive effect with other antiseptics, its non-cytotoxicity emerges as a safe alternative in wound care.
HOCl is a weak acid produced by the immune system as the first line of defense against invading pathogens.
Dense biofilm structure causes prolongation of wound infections. Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa are three bacteria that are frequently found in wound infections, form a biofilm, are difficult to treat, and HOCl is effective.
HOCl destroys bacteria by inhibiting bacterial growth, cell division and protein synthesis. A stabilized HOCl solution reduced cell numbers in biofilms and had favorable effects on fibroblast and keratinocyte migration in vitro compared to povidone iodine.
The HOCl solution eliminates the odor in the wound without causing discomfort to the patient, provides effective cleaning, debridement and healing.
ANTIMICROBIAL ACTIVITY
Some microorganisms proven by independent laboratories that HOCl solutions are effective;
BACTERIUM
Bacillus cereus, Bacillus circulans, Bacillus thuringiensis, Bordetella bronchiseptica, Chryseobacterium meningosepticum, Citrobaccter freundii, Corynebacterium amycolatum, Enterobacter aerogenes, Enterococcus faecalis, Escherichia coli, Haemophilus influenza, Klebsiella pneumonia, Listonella anguillarum, Methicillinresistant Staphylococcus aureus, Micrococcus luteus, Mycobacterium chelonae subsp. Chelonae, Mycobacterium fortuitum subsp. Fortuitum, Mycobacterium smegmatis, Paenibacillus alvei, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica (typhimurium), Serratia marcescens, Shigella Flexner, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Streptococcus pyogenes, Vancomycin-resistant Enterococcus faecium, Aspergillusniger, Candida albicans
FUNGUS
Aspergillus fumigatus, Epidermophyton, Microsporum, Rhizopus oryzae, Trichophyton rubrum
VIRUS
Hepatitis A,Hepatitis B (Hepadnaviridae), Hepatitis C (Flaviviridae), Influenza Virus (Orthomyxoviridae), Parainfluenza, Poliovirus, Adenovirus (Adenoviridae), Papillomavirus (Papovaviridae), Coxsackievirus(Picarnoviridae), Rotavirus (Reoviridae), HIV (Retroviridae, Flu A H1N1, H5N1, H9N2, H3N1, Coronavirus (COVID-19 (SARS-CoV-2))
SCOPE OF APPLICATION
1st and 2nd Degree Burns
I – IV. Stage Skin Ulcers
Open Wounds
Post-op Wounds
Crushes
Abrasions
Punctures
Diabetic Wounds (Including Foot Wounds)
Wound irrigation and debridement
Fungal Infections
Eye and Ear Wounds
Pressure Ulcers
USAGE
It can be used on wounds due to the antimicrobial, antibacterial and antifungal nature of CleanSmart Medical. It is applied topically twice a day by spraying or pouring onto the area after cleaning the other elements in the area to be applied. Due to its non-irritant and non-cytotoxic nature, there is no restriction on the amount of exposure to the area duringthe application of CleanSmart Medical.
